4BIO Capital founded Trogenix secures £70 million Series A financing to drive clinical development of potentially curative therapies for aggressive cancers

• Trogenix was founded by 4BIO as a spinout from the University of Edinburgh alongside Professor Steve Pollard and Dr Ken Macnamara in 2023
• Trogenix's breakthrough Odysseus® platform targets cancer cells to deliver precision therapies with curative “one and done” potential across multiple aggressive, treatment-resistant cancers
• £70 million financing round led by IQ Capital with participation from new investors Eli Lilly and Company, Meltwind, LongeVC, and Calculus Capital
  
  

London, United Kingdom, 6 October 2025 - 4BIO Capital (“4BIO” or “the Group”), an international venture capital firm unlocking the treatments of the future by investing in advanced therapies and other emerging technologies, announces that Trogenix Ltd (“Trogenix"), a pioneering biotech company founded by 4BIO and dedicated to developing innovative cancer therapies, has secured a £70 million ($95 million) Series A financing. The funding will enable the rapid advancement of Trogenix’s pipeline of potentially curative cancer therapies across multiple aggressive solid tumours into the clinic.
        
4BIO Capital invested in the Series A alongside IQ Capital which led the round, with new investors Eli Lilly and Company, Meltwind, LongeVC, and Calculus Capital. The round also included returning investors, the National Brain Tumor Society’s Brain Tumor Investment Fund and Cancer Research Horizons, a wholly owned subsidiary of Cancer Research UK, acting as its translational arm to advance bold research innovations, whose participation represents its largest investment to date.

Trogenix is revolutionising cancer treatment by combining the dual power of cancer cell killing and immune stimulation, delivered via a Trojan Horse approach that reawakens the immune system to provide long-term protection against tumour recurrence. Trogenix's lead programme in glioblastoma (GBM), one of the most aggressive and treatment-resistant brain cancers, is advancing toward clinical trials with first patient dosing anticipated in Q1 2026.

Dima Kuzmin, Co-founder and Managing Partner at founding investor, 4BIO Capital, and Chairman of Trogenix, said: “Trogenix perfectly embodies 4BIO’s innovation driving playbook, where we support breakthrough biotech companies to develop and deliver exceptional technologies, reach new areas of medicine and pioneer novel treatment possibilities.

“This investment, supported by an outstanding syndicate of leading investors, demonstrates the value that our hands-on, dedicated approach can have towards transforming innovative concepts into breakthrough therapies. Trogenix is now at a pivotal stage as it moves into the clinic and we look forward to continuing our close work with the company and its management, as they continue their rapid journey from breakthrough science towards potentially curative therapies across multiple aggressive cancers.”

Ken Macnamara, Chief Executive Officer at Trogenix, added: “This significant investment accelerates our lead programme in glioblastoma and follow-on programme in colorectal cancer liver metastases through the clinic, advances our pipeline in liver and lung cancers, and further enhances our Odysseus® platform. We are honoured to have the continued support of our founding investors, 4BIO Capital and I would like to thank Dima and the team for their tireless work and enthusiasm. I also thank and welcome our existing and new investors, who share our mission to deliver breakthrough treatments and pursue cures for the thousands of patients and families facing devastating diagnoses each year.”

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Contacts

About 4BIO Capital

4BIO Capital (“4BIO”) is an international venture capital firm focused on investing in advanced therapies and emerging modalities, to unlock the treatments of the future. 4BIO’s mission is to invest in, support, and grow early-stage companies solving technical bottlenecks that enable next generation therapeutics in areas of high unmet medical need, with the ultimate goal of ensuring access to these potentially transformative therapies for all patients. The 4BIO team comprises leading advanced therapy scientists and experienced life science investors with an unrivalled network within the advanced therapy sector and a unique understanding of the criteria that define a successful investment opportunity in this space. For more information, connect with us on LinkedIn and Twitter @4biocapital and visit www.4biocapital.com.

About Trogenix

Trogenix unites cutting-edge technologies in genomics, oncology, immunotherapy, and gene therapy to create a revolutionary therapeutic approach through its Odysseus® platform. Using proven AAV vectors, our proprietary Synthetic Super-Enhancers (SSEs) are delivered directly to tumour cells without detection. Our SSEs enable unprecedented precision in gene control, effectively revealing cancer to the body's immune system and killing tumour cells. For any cells escaping Trogenix's technology, our 'Trojan horse' can counter recurrence, offering potentially curative 'one-and-done' treatments for aggressive tumours. With our lead asset in glioblastoma entering the clinic, we're ready to transform treatment paradigms across multiple cancer types.

Trogenix was created in 2023 based on co-founder Professor Steve Pollard’s groundbreaking research at the University of Edinburgh - including its UK Centre for Mammalian Synthetic Biology and Institute for Regeneration and Repair - and the Cancer Research UK Scotland Centre. Incubated by 4BIO Capital, additional seed funding was provided through IQ Capital, Cancer Research Horizons, the US National Brain Tumor Society’s Brain Tumor Investment Fund, AIN Ventures and the University of Edinburgh’s venture investment fund, Old College Capital. In addition, Innovate UK provided an Investor Partnership grant in support of Trogenix’s preclinical research into its liver hepatocellular carcinoma and colorectal cancer liver metastases programmes.

For more information, visit www.trogenix.com.

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